2-D Speckle Tracking in Diagnosis and Prognosis of Acute Myocarditis


About this study

In this study, we attempt to evaluate the LV and RV myocardial mechanical properties   in patients with myocarditis during the acute and convalescent phases.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Patients admitted with a diagnosis of acute myocarditis or acute cardiomyopathy.

Exclusion Criteria:

Previous CABG, AMI, well-known CAD, heart failure, dilated cardiomyopathy, congenital heart disease, or poor echo window

  1. The echocardiographic images from EIMS of patients with acute myocarditis performed in acute and convalescence phase will be analyzed off-line.
  2. LV and RV deformation indices (global and segmental strain and strain rate in three directions [longitudinal, circumferential and radial ]) will be calculated via Syngo Velocity Vector image (VVI) software (Siemens Medical Solution, Malvern, PA).
  3. We will review and analyze the clinical data (such as symptoms, NYHA function class, and routine blood tests for myocarditis), EKG, CMR reports
  4. We will evaluate the diagnostic accuracy and prognostic values of LV and RV deformation and compare with findings of CMR and biopsy reports (when available).
  5. After completing all of the above, we will offer VVI software via 2D speckle tracking technique, as a clinical tool to the clinicians to evaluate its clinical ability in a small sample of patients (n= 30).


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Hector R. Villarraga, M.D.

Closed for enrollment

More information


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