Muscle and Adipose Trafficking of Fatty Acids Under Hypoinsulinemic and Fed Conditions

Overview

About this study

The goal of this study is to gain further insight into how different sources of fatty acids presented during two different metabolic challenges are trafficked by subcutaneous adipose tissue and skeletal muscle in a cohort of human adults with known variability in fat metabolism and insulin sensitivity. Tracking the allocation of these fatty acids into adipose and skeletal muscle lipid pools during metabolic states representative of fasted (elevated plasma free fatty acids and absent meal-derived fatty acids) and fed states (low plasma free fatty acids and high meal-derived fatty acids) can help elucidate rate-limiting steps in the biochemical pathways of fatty acid metabolism, ultimately providing insight into the mechanisms related to the development of such metabolic complications as obesity and insulin resistance. 

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Ages 18 to 64 years  
  • Participants will be nonsmokers and healthy enough to participate 
  • Normal hemoglobin >11.0 g/dL for women and men will be acceptable. 
  • Women of child-bearing potential will complete a urine pregnancy test at each visit 

Exclusion Criteria:

  • Participants with heart disease, severe lipid disorders, diabetes, liver disease and renal dysfunction
  • Participants cannot be taking medications known to influence FA metabolism

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Michael Jensen, M.D.

Closed for enrollment

Contact information:

Pamela Reich

(507) 255-6062

Reich.Pamela@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20314849

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