4DCT Imaging for Improved Diagnosis and Treatment of Wrist Ligament Injuries


About this study

The study seeks to determine whether the 4DCT imaging technique can be used to replace current invasive diagnostic tests for ligament injuries of the wrist.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  1. Unilateral scapholunate instability
  2. Point tenderness over the dorsal aspect of the scapholunate joint
  3. One or more of the following symptoms:
    • Positive Watson shift sign (Watson et al., J Hand Surg Am, 1988; 13:657-60);
    • Loss of grip strength;
    • Suspected pathology on previous fluoroscopy or MRI;
    • History of a fall on an outstretched hand
  4. Absence of symptoms on the contralateral wrist on physical exam

Exclusion Criteria:

  1. Obesity (BMI > 32)
  2. Previously-diagnosed rheumatological conditions or connective tissue diseases
  3. Inability to be appropriately positioned in the scanner for the imaging
  4. Congenital malformations of the wrist or forearm
  5. Diagnosed wrist osteoarthritis
  6. Age under 18 or over 60

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Kristin Zhao, Ph.D., M.S.

Open for enrollment

Contact information:

Tyson Scrabeck CCRP

(507) 538-1016


More information


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