Midodrine Hydrochloride in Early Sepsis


About this study

The investigators would like to determine if early administration of oral Midodrine in participants diagnosed with sepsis will impact blood pressures and decrease the need for and/or doses of intravenous pressor agents.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

 Patients presenting with sepsis admitted to the ICU and meeting all of the following criteria will be considered eligible to participate in the study:

  • Age greater than or equal to 18 years.
  • Able to tolerate oral medication either by mouth or by feeding tube.
  • Able to give consent for participation or have representative available to give consent.
  • Two or more blood pressure readings taken at least 15 minutes apart with MAPs ≤ 70 OR vasopressor use.
  • Two or more points scored on SOFA.
  • Treating consultant agrees to the study plan.

Exclusion Criteria

Patients meeting any one of the following criteria will be excluded from participation:

  • Women of child bearing age with the potential to become pregnant.
  • Current cardiogenic shock or KNOWN systolic heart failure with LVEF <30%.
  • Current bowel ischemia.
  • Recent Myocardial infarction (STEMI or Type 1 NSTEMI) within the past 3 months, evidence of active coronary ischemia or unstable cardiac rhythm.
  • Current use of Monoamine Oxidase Inhibitors (MAOIs).
  • Recent Stroke (within the past 3 months).
  • High dose vasopressor (norepinephrine more than 0.25 microgram/kg/min).
  • Lactate more than 8 mmol/L.
  • Midodrine use as a home medication.
  • Known allergy to midodrine.
  • Fludrocortisone acetate is a current home medication.
  • Contraindications to use: History of pheochromocytoma or thyrotoxicosis or Acute angle-closure glaucoma or ischemic bowel disease
  • History of peripheral vascular disease requiring intervention - stent or surgery in the past 3 months.





Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Ognjen Gajic, M.D.

Closed for enrollment

Jacksonville, Fla.

Mayo Clinic principal investigator

Pablo Moreno Franco, M.D.

Closed for enrollment

More information


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