A Study to Compare Post-exercise Treadmill versus Supine Bicycle Exercise Left Ventricular Outflow Tract Gradients Assessed by Echocardiography in Hypertrophic Cardiomyopathy


About this study

Exercise testing is routinely utilized in the evaluation of patient’s with hypertrophic cardiomyopathy to assess exercise capacity and also to evaluate the presence and severity of obstruction with an echocardiogram. Identifying significant obstruction is important in order to determine who could gain benefit from more invasive therapies like surgery.

There are several different exercise protocols available but it is not known which is the best method to assess the presence and severity of obstruction in hypertrophic cardiomyopathy. The purpose of this study is to determine which exercise protocol (supine bike or exercise treadmill) is better in these regards.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients with a diagnosis of hypertrophic cardiomyopathy (≥15mm wall thickness, non-dilated left ventricle, absence of a secondary cause of hypertrophy)
  • HCM patients referred for and capable of exercise testing
  • Patients who consent to participate in study

Exclusion Criteria: 

  • Patients who decline to participate in study
  • Inadequate image quality
  • Paced rhythm
  • Patient unable to exercise due to other comorbidities
  • Severe resting LVOT gradients (>100mmHg)
  • Severe symptoms (syncope, dyspnea, angina) / decompensated heart failure


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Steve Ommen, M.D.

Closed for enrollment

Contact information:

Steve Ommen M.D.

(507) 266-7078


More information


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