Normal and Pathological Aging


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Scottsdale/Phoenix, Arizona: 259-99
    Sponsor Protocol Number: 259-99

About this study

This study is being done to learn more about possible ways in which the brain might stop working properly before the first signs of Alzheimer’s disease. In addition, it is hoped that the methods used to study and identify brain abnormalities before memory loss begins, will help to identify people who might benefit most from preventive therapy. It is also hoped that it will create a faster way to study new preventative treatments when they become available to test.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Subjects with a first degree relative with dementia 
  • All subjects sign a consent form  
  • Medical history/ neurologic examination: requires good physical and mental health
  • Folstein mini-mental status exam (MMSE):  score at least 28 (62,63).
  • Mattis Dementia Rating Scale (DRS) (64):  score at least 135.
  • Hamilton Depression Rating Scale (17-item version) (65):  score less than 10.
  • Structured Clinical Interview for DSM-III-R:  establish normal psychiatric status

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Richard Caselli, M.D.

Open for enrollment

Contact information:

Bruce Henslin