A Study of Immune Profiling of Blood Samples in Patients with Benign and Malignant Thyroid Disorders


About this study

The purpose of this study is to perform a comprehensive immunophenotypic analysis of peripheral bloods samples from patients with benign and malignant thyroid disease. This data will be used to determine whether patients with advanced thyroid cancers have significantly altered numbers and/or subtypes of circulating immune cells, in particular immunosuppressive monocytes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients ≥18 of age
  • Able to consent at study entry 
  • Present to endocrinologists and/or endocrine-related clinics (T-NOD or Thyroid Clinic) and/or medical oncology clinic at MCR for the evaluation and/or treatment of thyroid-specified conditions or non-thyroid related cancers (ie melanoma, lung cancer)
    • This will include patients who present with thyroid cancer
      • Benign thyroid nodules
      • Hashimoto’s thyroiditis
      • Graves and thyroiditis following immune therapy with ipilimumab, nivolumab and/or pembrolizimuab.

Exclusion Criteria:

  • Patients unwilling and/or unable to provide consent 
  • Patients <18 years-old 
  • Pregnant patients
  • Any patient with active infection(s), fevers and/or immunodeficiency syndrome

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Mabel Ryder, M.D.

Closed for enrollment

More information


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