Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.See eligibility criteria
- Mayo Clinic patients of all ages (newborns to adults) diagnosed with HLHS will be identified both retrospectively (by diagnostic codes) and prospectively, and recruited following informed, written consent. DNA will be extracted from whole blood or saliva for CMA and WGS.
- Parents and siblings of the index case will be invited to participate by consenting to a screening echocardiogram and sample procurement for DNA extraction for WGS. Selected members of the extended family with congenital heart disease of any type will be contacted via a form letter to invite their participation in the study, which would include providing a copy of cardiac imaging reports and sample procurement for DNA extraction for WGS.
- Non-Mayo subjects would participate by providing a blood or saliva sample for WGS only.