A Study of Oxygen Cost of Exercise in Patients with and without Heart Failure


About this study

This study is being done to: (1) develop a simple tool to assess breathing muscle performance; (2) measure the oxygen cost of breathing during exercise; (3) measure the respiratory muscle blood flow requirements of hyperpnea during exercise; and (4) to quantify the energy cost of exercise in relation to disease severity.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:             

  • Heart Failure patients with a history of stable idiopathic dilated or ischemic cardiomyopathy (>1 yr, with >/ =1 episode of congestive failure requiring hospitalization)
  • New York Heart Association Class II and III symptoms
  • No history of dangerous arrhythmia's
  • Not pacemaker dependent
  • Less than class II obesity (BMI
  • No or minimal smoking history (<15 pk years)

CHF patients with an ejection fraction of less than 40% will be included in the Heart Failure with Reduced Ejection Fraction (HFrEF) group.

  • All other CHF patients will be included in the Heart Failure with Preserved Ejection Fraction (HFpEF) group. 

Controls will consist of age, gender , and BMI matched subjects 

  • No history of cardiovascular related abnormalities (i.e. Hx of shortness of breath, chest discomfort, abnormal rest or exercise ECG)
  • Non-obese (BMI 20-32)  
  • No or minimal smoking history (<15 pk yrs)

Exclusion Criteria:   

  • Unable to engage in exercise testing due to existing comorbidities.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Closed for enrollment

Contact information:

Briana Ziegler

(507) 255-7125


More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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