Alpha-1 AD Carriers and Lung Cancer Risk


About this study

The purpose of this study is to collect medical and family histories, blood and/or tumor tissue samples from patients who are being tested for or who have or had lung cancer. This study will help us to develop better ways to screen people at risk for lung cancer and develop better treatments for patients diagnosed with lung cancer. This study will also help us to learn whether certain genes (inherited factors from your parents) increase the risk of developing lung cancer.


Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • All primary lung cancer cases diagnosed between 2005 and 2009 who are ≥ 50 years of age and smoked cumulatively 20 pack-years or more of cigarettes
  • If a former smoker, stopped smoking within 10 years prior to diagnosis 
  • All Olmsted County residents diagnosed with primary lung cancer during 1997-2009 (approximately 400) will be included to continue our special emphasis of population-based analyses.  (Note: 200 cases may overlap between the two groups.)

Exclusion Criteria:

  • Patients who do not speak English 
  • From outside of Midwest region (MN, WI, IA, ND, SD, NE, KS, MO, IL, MI, IN, and OH) 
  • Are non-U.S. citizens or residents

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ping Yang, M.D., Ph.D.

Closed for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office


More information


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