A Study to Understand Crohn’s Disease using a Genetic Approach


About this study

The purpose of this study is to collect clinical information, blood and tissue samples from people with Crohn’s disease at the time of their bowel resection and at their standard of care colonoscopy after bowel resection. People without Crohn’s Disease are being asked only to give tissue samples at the time of a clinically indicated colonoscopy so their tissue can be compared to those that have Crohn’s Disease.

This study will compare the genetic codes (DNA) from active disease affected intestinal cells to these same cells from the same patient when they are without disease (inactive). We will be able to conclude which genetic codes are modified in the setting of active and inactive CD. This study has hopes of understanding the root cause of Crohn’s Disease.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients 18 years old and over
  • Confirmed diagnosis of Crohn’s Disease
  • Planned surgery for a ileocolonic bowel resection

Control group (Healthy Subjects)

  • Patients 18 years old and over
  • Heathy patient undergoing a screening colonoscopy

Exclusion Criteria:

  • Inflammatory bowel disease other than Crohn’s Disease


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

William Faubion, M.D.

Contact us for the latest status

Contact information:

Jessica Friton

(507) 284-0495


More information


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