A Study of High Dose Nicotine Patch Therapy for Smokeless Tobacco Users

Overview

About this study

The purpose of this study is to assess the effectiveness of high dose nicotine patch therapy to help the users of smokeless 'chewing' tobacco quit using long term or permanently. If found to be effective, chewers may use this treatment to help them quit and reduce their risk for negative health effects.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria

  • Age at least 18 years and at most 55 years
  • Report daily ST use for the past 12 months
  • Identify ST as their primary tobacco product
  • Use an average of ≥ 3 cans/pouches per week
  • In general good health determined by medical history and screening physical examination
  • Have been provided with, understand, and have signed the informed consent

Exclusion Criteria

  • Currently using (past 30 days) any other behavioral or pharmacologic tobacco treatment program
  • Currently pregnant or lactating
  • Has had unstable angina, myocardial infarction, or coronary angioplasty within the past 3 months
  • Has a history of arrhythmia or an abnormal tracing on the baseline EKG
  • Has a blood pressure of greater than 140/90 or a pulse of more than 110 beats per minute
  • Has a history of severe skin allergies or dermatoses
  • Has a history of intolerance to nicotine patches
  • Has another member of the household already participating in this study
  • Is taking a medication known to interact with nicotine (i.e., clozapine)
  • Is taking any prescription medication for depression or asthma

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Jon Ebbert, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

.
CLS-20312004

Mayo Clinic Footer