Non-Invasive Measures of Bronchial Blood Flow in Humans


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 06-002014
    Sponsor Protocol Number: 06-002014

About this study

This study is being done to: 1) develop a method to measure blood flow of the airways of humans, and 2) to look at the influence of one or all of the following interventions on changes in blood flow of the airways: an inhaled medication (a beta-agonist, the same medication that asthmatics use; or nitric oxide, a gas that relaxes the muscle of the airways and the vessels in the lungs), or histamine phosphate, a medication commonly used in the diagnosis of asthma), positional changes, breathing fast, hypoxia (low oxygen gas), and/or exercise.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria


Subjects will include up to 60 healthy men and women from the Rochester area ages 18-75 yrs with no underlying cardiac, pulmonary, or gastrointestinal abnormalities.

In addition, we will study up to 60 patients with stable class II-III heart failure who are non-symptomatic.

The heart failure subjects will not be exposed to hypoxia.


Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Open for enrollment

Contact information:

Minelle Hulsebus R.N.


More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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