Mitral Valve Prolapse in the Setting of Previous Open Heart Surgery


About this study

The purpose of this study is to compare outcomes of MitraClip vs open mitral valve repair in patients with severe mitral regurgitation (MR) due to mitral valve prolapse (MVP) in those who have already undergone a previous open heart surgery.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients with primary degenerative MR (MVP) in the setting of previous open heart surgery

Exclusion Criteria:

  • Patients who underwent a mitral valve procedure before.
  • Patients with:
    • functional mitral regurgitation
    • degenerative mitral regurgitation due other causes, such as ischemia and endocarditis

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Simon Maltais, M.D., Ph.D.

Closed for enrollment

More information


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