Clinical and Biological Studies of IgG4-Related Disease (IgG4-RD)


About this study

The purpose of this study is to determine the proper criteria for diagnosis of IgG4-related disease (IgG4-RD), identify strategies to avoid relapse and identify specific factors that underlie IgG4-RD disease pathophysiology.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age 18+.
  • Diagnosis of reactive lymphoid hyperplasia with or without IgG4+ plasma cells.
  • Diagnoses will include but not limited to orbital pseudolymphoma, IgG4-RD, pseudolymphoma NOS, autoimmune pancreatitis, retroperitoneal fibrosis, reactive lymphoid hyperplasia NOS.

Exclusion Criteria: 

  • Ages 1-17.
  • Malignant lymphoma.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Thomas Witzig, M.D.

Open for enrollment

More information


Publications are currently not available

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