Formation of a Genomic Library in Migraine


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 06-002002
    Sponsor Protocol Number: 06-002002

About this study

This study is being done to determine whether there are differences in hereditary information (genes) in people who have migraine and people who do not have migraine. Migraine is a disorder of the brain in which people have repeated attacks of severe headache, nausea, vomiting, light and sound sensitivity and in some cases, period during which the lose vision, have numbness and tingling and/or cannot speak normally. We are also interested in determining how genetic factors might help to predict what type preventative treatment a given migraine sufferer might respond to.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

The population studied will be for the unrelated case and control analyses, subjects between the ages of 18 and 100 who meet the IHS diagnostic criteria for migraine and who are willing to answer a brief screening diagnostic questionnaire and to donate 40 cc of blood or 5 ml of saliva for DNA processing

For the sampling of family pedigrees for the Whole Exome sequencing based studies the age range will be 10 to 100 to allow the enrollment of willing younger relatives of the affected proband subject.

In addition to subjects recruited from the patients, trainees and staff at the Mayo Clinic Rochester campus and from offsite visits with events in the community and on college campuses, subjects will be recruited from the Mayo Clinic Migraine research website.

Controls will be non-affected age and gender matched individuals unrelated to case subjects who do not meet diagnostic criteria for migraine or migrainous headaches.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Fred Cutrer, M.D.

Open for enrollment

Contact information:

Carey Huebert



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