Recovery of Left Ventricular Systolic Function and Atrial Fibrillation Recurrence after Restoration of Sinus Rhythm in Patients with Atrial Fibrillation


About this study

The objectives of this study are: (1) to analyze beat-to-beat variability and the variations of R-R interval to pre-preceding R-R interval (RRp/RRpp) ratio of left ventricular (LV) function by strain imaging (2D speckle tracking echocardiography) in patients with atrial fibrillation (AF) undergoing electrical cardioversion(ECV) or radiofrequency catheter ablation (RFCA) as a predictor of a recovery of LV function and volume after restoration of sinus rhythm , (2) to evaluate left atrial mechanics as a predictor of for AF recurrence after electrical cardioversion (ECV) or radiofrequency catheter ablation (RFCA)

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age more than 18 years
  • Non-valvular atrial fibrillation
  • AF of <12 months duration

Exclusion Criteria:

  • Mitral stenosis
  • Congenital heart disease
  • Cardiomyopathy (Infiltrative, hypertrophic, dilated or ischemic)
  • History of prior cardiac surgery
  • History of aortic or mitral valve prosthesis
  • Paced Rhythm
  • Thyrotoxicosis
  • History of moderate or greater mitral regurgitation or stenosis
  • Prior radiofrequency ablation or surgical maze procedure.
  • < 18 years of age
  • Inability to give consent.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Rowlens Melduni, M.D., M.P.H.

Closed for enrollment

More information


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