Beta-Blockers and Bone Health

Overview

About this study

The proposed study will directly examine whether bone mineral density (BMD) and bone microstructure are better preserved among HF patients on chronic β-blockers and account for the reports of decreased fracture. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

Inclusion Criteria:

  • Olmsted County residents
  • Age ≥50 yrs
  • History of HF diagnoses and either:
    • have been on β-blockers for at least 1 year
    • have not received chronic β-blockers for at least the past 3 years
  • Age and sex matched controls who do not have HF and who have not received chronic β-blockers for the past 3 years
  • Eligible women will be postmenopausal for at least 1 year

Exclusion Criteria:

  • Current or past history of malignancy that has required chemotherapy
  • Chronic renal insufficiency (GFR<30)
  • Bilateral hip replacements/pinning
  • History of current or past chronic glucocorticoid use (>3 months)
  • On pharmacologic doses of thyroid replacement
  • Current users of teraparatide, denosumab, oral or IV bisphosphonates, calcitonin, oral hormone replacement therapy (HRT), selective estrogen receptor modulators (SERMs), aromatase inhibitors in past 12 months, or androgen blockers   
  • Subjects who are not ambulatory

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Shreyasee Amin, M.D., M.P.H.

Open for enrollment

Contact information:

Louise McCready R.N.

(507)284-4329

mccready.louise@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20308307

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