Early Detection of Hemodynamic Decompensation in Humans


About this study

The purpose of this study is to use lower body negative pressure (LBNP) to evoke central hypovolemia as a non-invasive surrogate to hemorrhage during IV infusions of epinephrine and saline to determine the robustness of the ISR algorithm.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Healthy volunteers between the ages of 18 and 55

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Closed for enrollment

More information


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