Ischemic Preconditioning Prior to Cerebrovascular Interventional Procedures


About this study

The purpose of this study is to determine if patients receiving Remote ischemic conditioning (RIC) prior to elective endovascular treatment of intracranial aneurysms will have a reduction in rates of cerebral ischemia as detected onimaging when compared to a group of historical controls.  Our secondary aim is to determine if patients who receive ischemic preconditioning have any elevation in serum markers for cerebral ischemia.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients who are scheduled to undergo elective intracranial aneurysm treatment using either endosaccular coiling or flow diversion 

Exclusion criteria:

  • History of myocardial infarction within 30 days of the procedure
  • Age younger than 18 years
  • Pre-existing ischemic stroke
  • Pregnancy
  • Peripheral vascular disease affecting the upper limbs
  • Upper extremity vascular surgical
  • Stenting or angioplasty procedures
  • Patients enrolled in a different trial
  • Patients requiring radial access
  • Chronic kidney disease
  • Current drug therapy with sulfonamide or nicorandil

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

David Kallmes, M.D.

Closed for enrollment

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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