Ischemic Preconditioning Prior to Cerebrovascular Interventional Procedures


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 15-007104
    Sponsor Protocol Number: 15-007104

About this study

The purpose of this study is to determine if patients receiving Remote ischemic conditioning (RIC) prior to elective endovascular treatment of intracranial aneurysms will have a reduction in rates of cerebral ischemia as detected onimaging when compared to a group of historical controls.  Our secondary aim is to determine if patients who receive ischemic preconditioning have any elevation in serum markers for cerebral ischemia.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Patients who are scheduled to undergo elective intracranial aneurysm treatment using either endosaccular coiling or flow diversion 

Exclusion criteria:

  • History of myocardial infarction within 30 days of the procedure
  • Age younger than 18 years
  • Pre-existing ischemic stroke
  • Pregnancy
  • Peripheral vascular disease affecting the upper limbs
  • Upper extremity vascular surgical
  • Stenting or angioplasty procedures
  • Patients enrolled in a different trial
  • Patients requiring radial access
  • Chronic kidney disease
  • Current drug therapy with sulfonamide or nicorandil

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

David Kallmes, M.D.

Closed for enrollment


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