An Extension Studying the Pattern of Autonomic Dysfunction in Pure Autonomic Failure (PAF)


About this study


To systematically evaluate the pattern and severity of autonomic dysfunction in PAF

To assess the pattern of autonomic symptoms in patients with PAF

To assess rate of progression and evolution of symptoms/neurologic deficits in PAF

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria:

1) Orthostatic hypotension (defined as orthostatic blood pressure (BP) drop of at least 30mmHg systolic and/or 15mmHg diastolic within 5 minutes of head-up tilt)

2) Age 18-80 years


Exclusion criteria:

1) Clinical evidence of peripheral neuropathy, Adie's pupils, or prominent upper GI symptoms

2) Clinical evidence of central neurodegeneration (i.e., parkinsonism, cerebellar ataxia, or dementia)

3)  Absence of detectable titers of nAChR antibodies (if tested)

4) Absence of other medical conditions that could interfere with results of autonomic testing, including significant coronary artery disease, valvular heart disease, disorders of abnormal catecholamine synthesis


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Wolfgang Singer, M.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Tonette Gehrking CAP

(507) 284-4462

More information


Publications are currently not available

Study Results Summary

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Supplemental Study Information

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