Cardiotoxic Effects of Chemotherapy in Patients with Sarcomas


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 15-002714
    Sponsor Protocol Number: 15-002714

About this study

The purpose of this study is to determine if two-dimensional speckle tracking echocardiography (2D-STE) derived-strain can detect early myocardial dysfunction and thus predict cardiotoxicity in sarcoma subjects undergoing anthracycline therapy and to compare three dimensional speckle tracking echocardiography (3D-STE) to 2D-STE in the same group of patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Patients followed at Mayo Clinic and treated for sarcoma with doxorubicin as first-line treatment.

Exclusion Criteria: 

  • First-line treatment not including doxorubicin
  • Treatment performed outside of Mayo Clinic with different protocols
  • Age <18 years
  • Prisoners
  •  Subjects unable or unwilling to provide the written consent
  • LVEF <50%,

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Hector Villarraga, M.D.

Open for enrollment

Contact information:

Hector Villarraga M.D.



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