Cardiac MRE In Acute Myocardial Infarction


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 16-009048
    Sponsor Protocol Number: 16-009048

About this study

We have recently developed a new and novel imaging-based technique known as cardiac Magnetic Resonance Elastography (MRE) that is capable of differentiating differing regions of myocardial stiffness in the myocardium.  The condition which myocardial stiffness has been most studied and is thought to vary the most from normal is myocardial infarction. Cardiac MRE findings in acute infarction have not been established and the prognostic significance of cardiac MRE-defined infarct stiffness are unknown. The aims of this study are to compare cardiac MRE stiffness to microvascular obstruction in acute myocardial infarction, to determine the association of cardiac MRE infarct stiffness with left ventricular (LV) remodeling at approximately 6 months follow up, and to determine whether myocardial infarcts show increased stiffness at 6 months follow up.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Age ≥ 18 years
  • New myocardial infarction within 10 days of enrollment

Exclusion criteria:

  •  Contraindications to MRI scanning including internal defibrillators or pacemakers, cerebral aneurysm clips, or severe claustrophobia
  • Contraindications to gadolinium-based MRI contrast material, namely glomerular filtration rate less than or equal to 30mL/min
  •  Women who are pregnant or lactating

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Philip Araoz, M.D.

Closed for enrollment


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