Exploring Possible Mechanisms that Might Explain Potential Vasodilator and Sensory Effects of TJ-68

Overview

About this study

We will determine if a) glycyrrhetic acid (GA, a key component of TJ-68) evokes vasodilation, and b) if glycyrrhetic acid alters the TRP mediated sensory response to local heating. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

Inclusion Criteria:

  • Healthy subjects between 18-40 years old
  • Non-obese 
  • Non-smokers

Exclusion Criteria:

  • Hypertension 
  • Hyperlipidemia 
  • Smoking 
  • Heart disease 
  • Diabetes Autonomic disorders   
  • Other conditions or medications that might normally alter exercise capacity or responses)

All inclusion and exclusion criteria are at the discretion of the Principal Investigator. 

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20306569

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