Exploring Possible Mechanisms that Might Explain Potential Vasodilator and Sensory Effects of TJ-68


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 16-008406
    Sponsor Protocol Number: 16-008406

About this study

We will determine if a) glycyrrhetic acid (GA, a key component of TJ-68) evokes vasodilation, and b) if glycyrrhetic acid alters the TRP mediated sensory response to local heating. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Healthy subjects between 18-40 years old
  • Non-obese 
  • Non-smokers

Exclusion Criteria:

  • Hypertension 
  • Hyperlipidemia 
  • Smoking 
  • Heart disease 
  • Diabetes Autonomic disorders   
  • Other conditions or medications that might normally alter exercise capacity or responses)

All inclusion and exclusion criteria are at the discretion of the Principal Investigator. 

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Open for enrollment

Contact information:

Shelly Roberts R.N.




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