Learning More about How your Brain Works with Decreased Levels of Oxygen


About this study

The specific aim of this proposal is (1) to develop a human model of hypoxia in which cerebrovascular reactivity and cognitive function can be simultaneously measured and (2) develop pilot data in our laboratory on the relationship between cerebrovascular reactivity and cognitive function during three different hypoxic conditions with and without addition of inspired CO2 as a mechanism to maintain cerebral blood flow.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Adult male and female, 18-35 years of age;

  • Able to understand the study, and having understood, provide written informed consent in English

  • Subject must be in general good health as determined by medical history, physical exam and by physician investigator

  • If female and of child bearing potential, have a negative pregnancy test prior (within 48 hours) to participating in the study.


Exclusion Criteria:

  • Subject is unable or unwilling to participate in all aspects of the study.

  • Females who are pregnant

  • Significant medical history including neurological disease, learning disability or cognitive dysfunction, pulmonary disease, or cardiovascular disease


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Timothy Curry, M.D., Ph.D.

Closed for enrollment

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