Effect of Spasticity on Motor Neuron Properties

Overview

About this study

The purpose of this study is to compare motor neuron properties in adolescents and adults with and without spastic cerebral palsy (sCP).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Individuals with sCP:
- Age 15 or older with a known diagnosis of cerebral palsy and spasticity.
Individuals without sCP:
- Age 15 and older

Exclusion Criteria:

Individuals with sCP:
- Botulinum toxin injection to the muscle of interest in the past 3 months
- A history of phenol neurolysis to the fibular nerve or sciatic nerve
- Active titration of oral baclofen or anti-epileptic medications
- History of a selective dorsal rhizotomy
- Presence of a baclofen pump
- Having any other neuromuscular disorder
Individuals without sCP:
- Presence or history of a peripheral or compressive neuropathy
- Myopathy
- Injury to the nerve or muscle of interest
- Abnormality of the central nervous system (stroke, traumatic brain injury (with presence of spasticity or movement difficulties), spinal cord injury, neurodegenerative condition, or central nervous system tumor)
- Any other neuromuscular disorder

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Joline Brandenburg, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Joline Brandenburg, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials