Effect of Spasticity on Motor Neuron Properties


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 15-006759
    Sponsor Protocol Number: 15-006759

About this study

The purpose of this study is to compare motor neuron properties in adolescents and adults with and without spastic cerebral palsy (sCP).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Individuals with sCP:
    • Age 15 or older with a known diagnosis of cerebral palsy and spasticity. 
  • Individuals without sCP:
    • Age 15 and older

Exclusion Criteria: 

  • Individuals with sCP:
    • Botulinum toxin injection to the muscle of interest in the past 3 months
    • A history of phenol neurolysis to the fibular nerve or sciatic nerve
    • Active titration of oral baclofen or anti-epileptic medications
    • History of a selective dorsal rhizotomy
    • Presence of a baclofen pump
    • Having any other neuromuscular disorder
  • Individuals without sCP:
    • Presence or history of a peripheral or compressive neuropathy
    •  Myopathy
    • Injury to the nerve or muscle of interest
    • Abnormality of the central nervous system (stroke, traumatic brain injury (with presence of spasticity or movement difficulties), spinal cord injury, neurodegenerative condition, or central nervous system tumor)
    • Any other neuromuscular disorder

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Joline Brandenburg, M.D.

Open for enrollment

Contact information:

Shirley Kingsley-Berg CCRP



More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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