Transapical and Transfemoral TAVR, Two Different Patient Populations with Possible Similar Clinical and Cardiac Mechanics Outcomes


About this study

Compare transapical and transfemoral TAVR as regards clinical outcomes (both beneficial including improvement in heart failure class (NYHA) and reduced number of hospitalizations; and adverse including mortality and MACE.) Also, to compare cardiac mechanics’ outcomes in the short and intermediate follow up and correlate the baseline, percent change and final cardiac mechanics values with the clinical outcomes. So that this all comes down to being able to provide these information to the patients if there appeared to be a correlation between cardiac mechanics and clinical outcomes:

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Consecutive patients who have had either Transapical or transfemoral TAVR

Exclusion Criteria: 

  • Unsucessful procedures e.g. Procedures complicated with more than moderate aortic incompetence.
  • Arrhythmias e.g. conduction delays and atrial fibrillation
  • Patient denied Mayo Clinic authorization to participate in research

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Sorin Pislaru, M.D., Ph.D.

Closed for enrollment

Contact information:

Sorin Pislaru M.D., Ph.D.

(507) 266-3626

More information


Publications are currently not available

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