Vascular Boot Warming Program After Acute Deep Vein Thrombosis (DVT) ± Pulmonary Embolism (PE)


About this study

The Researchers are studying whether a vascular boot warming program plus standard of care anticoagulation can be a safe and effective method to resolve Deep Vein Thrombosis (DVT) ±Pulmonary Embolism (PE) earlier and prevent development of post-thrombotic syndrome (PTS). Additionally, to learn whether a more detailed imaging of the affected lower extremities will provide a more accurate and reliable method to guide treatment for this condition.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Able to tolerate wearing a vascular boot, if randomized to this group.
  • Diagnosis of acute DVT±PE (within 24 - 48 hours) and received approximately 24 hours of anticoagulation prior to starting the study.

Exclusion Criteria:

  • Unable to tolerate wearing a vascular boot
  • Unable to comply with keeping log of activity/ of wearing a vascular boot.
  • Weight > 300 pounds. (weight limit for the venous plethysmography chair)
  • Previous history of DVT or PE.
  • On anticoagulation for another purpose (example stroke prevention with atrial fibrillation).
  • Patients who do not accept to participate in research studies.
  • Pregnant women will not be allowed to participate
  • Patients less than 18 yrs

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Waldemar Wysokinski, M.D., Ph.D.

Closed for enrollment

More information


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