Left Ventricular Remodeling and Echocardiographic Predictors of Mortality in Severe Aortic Stenosis


About this study

The purpose of this study is to compare 3D measurements to conventional 2D measurements of left ventricular size and mass, left ventricular systolic function, and left ventricular diastolic function in patients with severe aortic stenosis and determine whether there are significant differences in remodeling between men and women and in those with and without a history of hypertension. The study will also aim to identify echocardiographic markers associated with NYHA symptom class, risk of atrial fibrillation, the need for aortic valve operation, or cardiac death or persistent heart failure after aortic valve replacement for severe aortic stenosis.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adults ≥ 18 years of age undergoing aortic valve replacement
  • Severe aortic stenosis
  • Currently in sinus rhythm

Exclusion Criteria: 

  • Moderate or greater concomitant valve disease

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Jeremy Thaden, M.D.

Closed for enrollment

More information


Publications are currently not available

Mayo Clinic Footer