Biomarker for Skeletal Loading Using Triaxial Accelerometers


About this study

This study is intended to develop and validate a novel wearable dynamic loading assessment tool and to demonstrate the association between the measures from this tool and hip BMD.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Post-menopausal for at least 1 year
  • Willingness to participate in the study
  • Provided informed consent

Exclusion Criteria

  • Less than 2 years (self-reported) of starting, stopping or modifying any osteoporosis treatment such as hormone replacement therapy, PTH, or bisphosphonates, or currently taking prescription medication for BMD improvements or which may result in BMD changes
  • Induced menopause
  • Use of an assistive device while walking, obvious limp while walking, any lower body amputations or orthotics
  • Prolonged bed rest
  • A BMI of greater than 40
  • A history of hip surgery, lower-limb fracture, hip or knee joint replacement on the non-dominant side
  • Have a current lower extremity injury
  • Have undergone chemotherapy, and long-term or current use of corticosteroids, such as prednisone
  • Moderate to severe hip or knee arthritis
  • Self-reported medical conditions that could affect the skeletal system such as diabetes or other diagnosed endocrinological abnormalities, current or prior mental illness or clinical depressions, symptomatic lower body joint abnormalities, medical conditions that may affect balance, traumas requiring medical attention in the last year or any conditions which would preclude completion of physical testing, any symptomatic nervous system or motor skills disorders, Paget’s disease, hyperthyroidism, chronic renal failure, rickets, hypocalcemia, hypercalcemia etc.
  • Self-reported history within the last 5 years of regular participation in impact or jumping exercises or sports (i.e. jogging, running, tennis, softball, basketball, volleyball, skiing etc.).
  • Self-reported current smoker, COPD including severe allergies or asthma


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Emma Fortune, Ph.D.

Closed for enrollment

Contact information:

Christine Huyber


More information


Publications are currently not available

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