Cardiac Troponin Fragments in Peripartum Cardiomyopathy

Overview

  • Study type

    Observational
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 14-008640
    Sponsor Protocol Number: 14-008640

About this study

The primary aim of this study is to measure cardiac troponin (cTn) values with high sensitivity assays in patients with acute peripartum cardiomyopathy (PPCM) in order to determine whether specific fragments exist in these patients. We will also determine whether cTn fragment profile correlates with left ventricular recovery. Finally, we aim to establish a Bio bank in order to facilitate further investigations.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Patient Group:
    • Development of cardiac failure in the last month of pregnancy or within 5 months of delivery
    • Absence of an identifiable cause for the cardiac failure
    • Absence of recognizable heart disease prior to the last month of pregnancy
    • LV systolic dysfunction demonstrated by classical echocardiographic criteria: ejection fraction <45% or fractional shortening <30%, or both
  • Control Group:
    • history of acute myocardial infarction

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Lori Blauwet, M.D.

Closed for enrollment

Contact information:

Jessica Bauman

(507)266-1123

Bauman.Jessica@mayo.edu

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CLS-20304516

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