Cardiac Toxicity Following Radiotherapy


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 14-002738
    Sponsor Protocol Number: 14-002738

About this study

The purpose of this study is to determine if stress cardiac magnetic resonance imaging (MRI) imaging will allow us to detect radiation-related cardiac toxicity before other evaluation modalities would allow.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Histological confirmation of malignancy.
  • Patient to undergo radiotherapy with cardiac V20 > 2% or mean cardiac dose > 2 Gy.
  • Age ≥ 18 years.
  • ECOG Performance Status (PS) 0, 1 or 2.
  • Negative pregnancy test done ≤7 days prior to registration, for women of childbearing potential only
  • Ability to undergo stress cardiac MRI.
  • Provide informed written consent.

Exclusion Criteria: 

  • Medical contraindication to stress cardiac MRI (including contraindication to gadolinium or
  • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Nadia Laack, M.D.

Closed for enrollment


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