His Bundle Pacing in Bradycardia and Heart Failure


About this study

Participants in this study will either have heart failure (HF) and are scheduled to undergo cardiac resynchronization therapy pacemaker (CRT-P) or cardiac resynchronization therapy defibrillator (CRT-D) implantation, or have atrioventricular (AV) block and are scheduled to undergo dual chamber pacemaker implantation. In this study additional heart rhythm measurements will be collected during the implant procedure to better understand how His bundle and/or parahisian pacing (HISP) effects electrical conduction in the hearts of patients with HF or AV block. The hypothesis is that His bundle or parahisian pacing (HISP) may normalize atrioventricular (AV) conduction with a narrow combination of the Q wave, R wave and S wave (QRS complex) in functional bundle branch block or conduction delay in patients with heart failure (HF).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

HF Group

- Recommended to undergo CRT-P or CRT-D implantation

- LBBB, RBBB or IVCD with a QRS duration > 120 ms

- LVEF ≤ 35%

AV Block Group

- Recommended to undergo dual chamber pacemaker implantation

- Second or third degree AV block

Exclusion Criteria:

- Age < 18 years

- Pregnant

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 9/27/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Yongmei Cha, M.D.

Open for enrollment

Contact information:

Yongmei Cha M.D.

(507) 255-7369


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