Stress Echocardiography in Mixed and Multi Valvular Heart Disease


About this study

The purpose of this study is to: investigate the diagnostic utility of stress echocardiography (SE) in the evaluation of patients with mixed and mult-valvular heart disease (mx/ml-VHD), evaluate the hemodynamic impact of exercise on mx/ml-VHD compared to those with isolated valve disease, study the prevalence and natural history of mx/ml-VHD, and identify clinical, echocardiographic and biochemical markers that can be used to identify patients with mx/ml-VHD who are at higher risk for future cardiovascular events.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • All adult patients with at least moderate mx/ml-VHD and those with at least moderate single valve disease who had underwent a clinically indicated stress echocardiography study for their VHD prior to the date of IRB submission.
  • All adult patients who would be scheduled for a clinically indicated stress echo study in the future (from the date of IRB submission, up to 31st Dec 2022).

Exclusion Criteria: 

  • Patients < 18 years old



Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ratnasari Padang, M.B.B.S., Ph.D.

Closed for enrollment

Contact information:

Patricia Pellikka M.D.

(507) 266-1376

More information


Publications are currently not available

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