A Study of the Role of the Forkhead Box O3a BNIP3 Pathway in Human Cardiovascular Disease


About this study

The purpose of this study is to collect cardiac biopsies and assess the activity of the signaling pathway in patients with cardiovascular disease by  using transmission electron microscopy to study mitochondrial structure and morphology and by assessing the biology of the genes and proteins of the FOXO3a effector, BNIP3.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Age 18 or older
  • Should have a recent echo, preferably within one to three months prior to surgery
  • Diabetic patients: A1C within 1-3 months of enrollment

Exclusion Criteria

  • Acute Coronary Syndrome (STEMI or NSTEMI) within the past 6 months
  • History of myocarditis or pericarditis, infiltrative or hypertrophic  cardiomyopathy
  • Severe mitral regurgitation or congenital heart disease
  • Prior cardiac surgery
  • Any non-cardiac disease or condition that can significantly influence cardiac function
  • Advanced renal failure (CKD stage 4-5), chronic anemia (hematocrit < 30), bleeding diathesis
  • Any condition that could affect patient’s ability to provide informed consent
  • History of alcohol or drug abuse
  • Women of child-bearing potential

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Margaret Redfield, M.D.

Closed for enrollment

More information


Publications are currently not available

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