A Study of the Safety and Effectiveness of EG-1962 Compared to Standard of Care Oral Nimodipine for Adults with Aneurysmal Subarachnoid Hemorrhage


About this study

The purpose of this study is to compare the effectiveness and safety of EG-1962 to the standard of care oral nimodipine for the treatment of adult patients who have an aneurysmal subarachnoid hemorrhage.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Has had a ruptured saccular aneurysm confirmed by angiography and repaired by neurosurgical clipping or endovascular coiling
  • Has an external ventricular drain in place
  • Subarachnoid hemorrhage on computed tomography (CT) scan is of grade 2-4 on the modified Fisher scale
  • WFNS grade 2, 3, or 4

Exclusion Criteria

  • Major complication during aneurysm repair such as, but not limited to, massive intraoperative hemorrhage, brain swelling, arterial occlusion or inability to secure the ruptured aneurysm
  • Angiographic vasospasm prior to randomization
  • Evidence of a cerebral infarction with neurological deficit

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

William Freeman, M.D.

Closed for enrollment

More information


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