A Study of the Effect of Probiotic Supplements on Weight Loss, and the Connection it has to the Bacterial Environment of the Digestive System after Bariatric Surgery

Overview

About this study

The purpose of this study is to assess the associated effects of probiotic supplements on weight loss, visceral and total body fat, and changes in the biological environment of the digestive tract in patients who have had bariatric surgery.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria                                           

  • > 18 and < 65 years of age
  • Recruited from the Mayo Clinic bariatric surgery clinic
  • Meets one of the National Institute of Health’s criteria for bariatric surgery
    • Body mass index (BMI) > 40 kg/m2 
    • BMI > 35 kg/m2 with significant weight-related comorbidities
  • Is not on chronic antibiotic therapy        
  • Does not have active systemic illness

Exclusion Criteria

  • Type 1 or 2 diabetes due to the known pre-existing changes in the gut microbiome in this population
  • Has had exposure to probiotics, prebiotics or antibiotics in the preceding 4 weeks
  • Has an allergy to antibiotics precluding the use of standard peri-operative antibiotics cefazolin and metronidazole

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Meera Shah, M.B., Ch.B.

Open for enrollment

Contact information:

Paula Giesler R.N.

(507)255-8345

Giesler.Paula@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20258286

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