Early Coronary Angiography Versus Delayed Coronary Angiography

Overview

About this study

This study is a pilot, multi-centered, randomized, clinical trial to evaluate the safety and efficacy of performing early Coronary Angiography (CAG) versus no early CAG in post-cardiac arrest patients without ST segment elevation. Safety will be assessed by evaluating the association of major adverse events (re-arrest, bleeding, pulmonary edema, hypotension, acute renal insufficiency, and pneumonia) with early coronary angiogram. Efficacy will be assessed by a composite endpoint of improved left ventricular regional and global function (both regional wall motion analysis and left ventricular ejection fraction) as measured by echocardiography prior to hospital discharge and favourable neurological function (Cerebral Performance Categories 1 or 2) at discharge.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  1. All successfully resuscitated out-of-hospital cardiac arrest patients with a suspected cardiac etiology for their non-traumatic arrest
  2. Age greater than 18 years
  3. The post resuscitation ECG shows no evidence of ST segment elevation

Exclusion Criteria:

  1. Non-resuscitated (no sustained pulse and BP)
  2. Presence ST segment elevation or new left bundle branch block present on the post-resuscitation ECG
  3. Suspected non-cardiac etiology for their arrest such as respiratory failure, asphyxia, pulmonary embolus, shock, trauma, drug overdose, or CNS bleed as likely cause of the cardiac arrest
  4. Known "Do Not Resuscitate" status
  5. Minors (<18 years old)
  6. Prisoners
  7. Significant bleeding or blunt trauma
  8. Known or confirmed pregnancy test by urinalysis
  9. Patients who are known to have received any other investigational therapies within the 30 days prior to enrollment or during study duration will be excluded unless these studies have been reviewed and approved by the Study Steering Committee.
  10. Known "opt out" choice; wearing Opt-out band for any EFIC approved study or on an "Opt-out" list

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jacob Jentzer, M.D.

Closed for enrollment

Contact information:

Dereen Ernst R.N.

(507)255-1202

ernst.dereen@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

.
CLS-20258279

Mayo Clinic Footer