A Study to Compare the Occurrence of Elevated Liver Enzymes Between Adult Patients Receiving Daily IV Fat Emulsions versus Only Three Times per Week


About this study

The purpose of this study is to compare the incidence and frequency of elevated liver enzymes or parenteral (IV) nutrition-associated liver disease, in adult patients who are receiving daily versus three time per week soybean based intravenus (IV) fat emulsions.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Age 18 to 75 years old inclusive, at initiation of Home Parenteral Nutrition
  • Able to provide informed consent
  • Anticipated duration of HPN greater than 3 months
  • Not previously on HPN at Mayo Clinic or elsewhere
  • Agree to be managed by the Mayo HPN program
  • No history of alcohol addiction
  • No known liver disease (as determined by review of EMR)

Exclusion Criteria

  • Pregnant women
  • Failure to provide consent
  • On HPN for less than three months
  • Has previous proven addiction and dependence to alcohol and/or heavy alcohol consumption reported (during history or reported in the EMR)
  • Documented liver disease
  • Will not be managed by the Mayo Clinic HPN team
  • Has active infection (as determined by the clinician) at the initiation of HPN

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Ryan Hurt, M.D., Ph.D.

Closed for enrollment

More information


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