A Study of Changes to the Microbe Environment in the Intestines of Obese People who Modify Their Diet and Lifestyle

Overview

About this study

The purpose of this study is to assess changes that occur in the intestine microbe environment of obese people as they perticipate in a structured diet and lifestyle modification.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Obese subjects
    • Adults aged 18 and above
    • Overweight or obese (BMI of 25 or greater)
    • DAHLC/HLP eligible members who are able to access DAHLC support services
  • Control subjects
    • Adults aged 18 and above
    • Overweight or obese (BMI of 25 or greater)
    • Preferably lives in the same household, such as a spouse, relative, or contact of the subject, with a similar weight, and not exercising on a regular basis

Exclusion Criteria

  • Obese subjects
    • Known diagnosis of inflammatory bowel disease, microscopic colitis, celiac disease or other inflammatory conditions
    • Antibiotic use within the past 4 weeks
      • Can be enrolled after a four week washout period and subsequent use during the 6 month study duration does not exclude them
    • Bowel preparation for colonoscopy within the past week
    • Pregnancy or plans to become pregnant within the study time frame
    • Vulnerable Adults
    • Any other disease(s), condition(s) or habit(s) that would interfere with completion of the study or, in the judgment of the investigator, would potentially interfere with compliance to this study or adversely affect study outcomes
  • Control subjects
    • Known diagnosis of inflammatory bowel disease, microscopic colitis, celiac disease or other inflammatory conditions
    • Antibiotic use within the past 4 weeks 
      • Can be enrolled after a four week washout period and subsequent use during the 6 month study duration does not exclude them
    • Bowel preparation for colonoscopy within the past week
    • Pregnancy or plans to become pregnant within the study time frame
    • Vulnerable Adults
    • Any other disease(s), condition(s) or habit(s) that would interfere with completion of the study or, in the judgment of the investigator, would potentially interfere with compliance to this study or adversely affect study outcomes

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Purna Kashyap, M.B.B.S.

Closed for enrollment

More information

Publications

Publications are currently not available
.

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