A Study to Identify Risk Factors from any Reason for Hospital Readmission, Death, or Declining Health in Older Persons who were Hospitalized with a Heart Attack


About this study

The purpose of this study is to gather data to develop a risk model that can be used to help doctors predict the recovery of older persons who have been admitted to the hospital with a heart attack. Information will be collected on hospital readmissions, death, and decline in health from any cause following a heart attack. The goal is help older people in the future make well-informed decisions about their health care during a heart attack.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥75 years upon admission to the hospital
  • Elevation of cardiac markers within 24 hours of presentation to the hospital 
    • Troponin must rise above the upper limit of normal established by the hospital as a determinate of cardiac injury
  • Any one of the following
    • Symptoms of ischemia
    • ECG with ischemic changes
    • Imaging evidence of Infarction
    • Intracoronary thrombus on angiography

Exclusion Criteria:

  • Patient transferred from another hospital with a length of stay >48 hours at the referring hospital
  • Refused Informed Consent
  • Decisional impairment with no legally authorized representative
  • AMI is secondary to chest trauma
  • AMI is secondary to in-patient procedure or surgery
  • History of heart transplant
  • Non-English/Non-Spanish speaking
  • Inability to complete interview (e.g. comatose or aphasia)
  • Inability to contact for follow-up (e.g. no access to phone, not living in the country)
  • Currently a prisoner
  • Death prior to enrollment
  • Previously enrolled in SILVER-AMI
  • Troponin elevation is the result of apical ballooning syndrome (i.e., Takotsubo)

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Patricia Best, M.D.

Closed for enrollment

More information


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