Exparel Transversus Abdominis Plane Block vs. Intrathecal Analgesia In Colorectal Surgery


About this study

This study is prospective, randomized trial in which EXPAREL TAP block is compared to standard IT opioid administration, in relieving postoperative pain, decreasing length of stay, and use of narcotic medication.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • All patients undergoing elective laparoscopic or open colorectal resections who are eligible for IT, and able to be enrolled in ERP.
    • Age >18 years
    • BMI <40
    • Ability to understand and read English

Exclusion Criteria:

  • Not able or unwilling to sign consent.
    • Currently pregnant or lactating.
    • Patients with chronic pain, requiring daily opiate use at time of surgery.
    • Patients intolerant of opiates, NSAIDS, acetaminophen or local anesthetics.
    • Patients requiring emergent surgery.
    • Abdominoperineal resections
    • Any contraindications to neuraxial analgesia (coagulopathy, localized infection at the potential site of injection, pre-existing spinal canal pathology)
    • Patients with a diagnosis of inflammatory bowel disease

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Dorin Colibaseanu, M.D.

Closed for enrollment

Rochester, Minn.

Mayo Clinic principal investigator

Dorin Colibaseanu, M.D.

Closed for enrollment

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