A Study Using Magnetic Resonance Elastography to Assess Heart Muscle Stiffness in Patients with Cardiac Amyloidosis


About this study

The purpose of this study is to use magnetic resonance elastography to assess heart muscle stiffness in patients with cardiac amloidosis compared to normal subjects.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Normal Subjects
    • Age ≥ 18 years
    • Normal heart sounds
    • Normal breath sounds
    • Measured systolic blood pressure < 140 mm Hg
    • Measured diastolic blood pressure < 90 mm Hg
  • Cardiac Amyloidosis
    • Tissue diagnosis of amyloidosis and left ventricular maximal wall thickness > 12 mm by echocardiography or MRI

Exclusion Criteria

  • Normal Subjects
    • History of angina, coronary artery disease, heart failure, hypertension, hypertensive medication, valvular heart disease, congenital heart disease, diabetes 
    • Contraindications or relative contraindications to MRI scanning, namely internal defibrillators or pacemakers, cerebral aneurysm clips, severe claustrophobia, and pregnancy or suspected pregnancy (self-reported)
  • Cardiac Amyloidosis
    • Contraindications or relative contraindications to MRI scanning (same as with normal subjects)

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Philip Araoz, M.D.

Closed for enrollment

Contact information:

David Krahn



More information


Publications are currently not available

Mayo Clinic Footer