A Study of Magnetic Resonance Elastography to Measure Heart Muscle Stiffness in Patients with Hypertrophic Cardiomyopathy


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 15-002100
    Sponsor Protocol Number: 15-002100

About this study

The purpose of this study is to use magnetic resonance elastography to assess heart muscle stiffness in patients with hypertrophic cardiomyopathy compared to normal subjects.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria

  • Normal subjects
    • Age ≥ 18 years
    • Normal heart sounds
    • Normal breath sounds
    • Measured systolic blood pressure < 140 mm Hg
    • Measured diastolic blood pressure < 90 mm Hg 
  • Hypertrophic cardiomyopathy
    • A clinically-indicated cardiac MRI ordered for evaluation of hypertrophic cardiomyopathy

Exclusion Criteria

  • Normal Subjects
    • History of angina, coronary artery disease, heart failure, hypertension, hypertensive medication, valvular heart disease, congenital heart disease, diabetes 
    • Contraindications or relative contraindications to MRI scanning, namely internal defibrillators or pacemakers, cerebral aneurysm clips, severe claustrophobia, and pregnancy or suspected pregnancy (self-reported) 
  • Hypertrophic cardiomyopathy
    • History of prior myocardial infarction, myocarditis, or prior heart transplantation

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Philip Araoz, M.D.

Closed for enrollment


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