A Study for Sources of Pulmonary Congestion Associated with Heart Failure


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 10-000482
    Sponsor Protocol Number: 10-004968

About this study

The purpose of this study is to measure and identify chest fluid volumes associated with heart failure and to determine their impact on lung structure and function, and also assess the effect of body position on shifts in fluid and the effects of this on lung function, mechanics and gas exchange.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria  

  • Age 18 to 85 years old.
  • Equal number of males and females.
  • Participants recruited to three experimental groups:
    • Class I-II heart failure patients;
    • Class III-IV heart failure patients;
    • Age, BMI and sex matched healthy control subjects.

Exclusion Criteria  

  • Pacemaker dependent.
  • If they currently smoke.
  • If they are allergic to the CT contrast material.
  • If participating in an aim of the study in which an esophageal balloon catheter will be used, subjects will be excluded if:
    • They are allergic to latex; or
    • If they have a history of nose bleeds.                      

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Open for enrollment

Contact information:

Briana Ziegler



More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


Mayo Clinic Footer