A Study for Sources of Pulmonary Congestion Associated with Heart Failure


About this study

The purpose of this study is to measure and identify chest fluid volumes associated with heart failure and to determine their impact on lung structure and function, and also assess the effect of body position on shifts in fluid and the effects of this on lung function, mechanics and gas exchange.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria  

  • Age 18 to 85 years old.
  • Equal number of males and females.
  • Participants recruited to three experimental groups:
    • Class I-II heart failure patients;
    • Class III-IV heart failure patients;
    • Age, BMI and sex matched healthy control subjects.

Exclusion Criteria  

  • Pacemaker dependent.
  • If they currently smoke.
  • If they are allergic to the CT contrast material.
  • If participating in an aim of the study in which an esophageal balloon catheter will be used, subjects will be excluded if:
    • They are allergic to latex; or
    • If they have a history of nose bleeds.                      

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Open for enrollment

Contact information:

Briana Ziegler



More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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