Manage Diarrhea in Patients With Multiple Myeloma While Receiving Conditioning Chemotherapy for Autologous SCT


About this study

To understand the mechanisms associated with diarrhea in patients receiving conditioning chemotherapy prior to autologous stem cell transplantation and to test the effects of the studied therapies on mechanisms that may be involved in the pathophysiology of diarrhea associated with conditioning chemotherapy.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥18 years, male or female
  • Diagnosis: multiple myeloma undergoing Autologous Stem Cell Transplantation (SCT)
  • Planning to receive conditioning chemotherapy (Melphalan) for autologous stem cell transplantation and standard prophylactic antibiotics treatment.
  • Can drink 200ml of mannitol and agrees to undergo stool, urine, and blood checks 3 times during the study.
  • Agrees and able to take the investigational products or placebo starting from the day of completing conditioning therapy for a total of 4 weeks

Exclusion Criteria:

  • Patients with history of inflammatory bowel disease will be excluded from the study.
  • Patients with prior GI tract surgical (small or large bowel) resections
  • The concurrent presence of systemic light chain amyloidosis
  • Subject has known allergy or intolerance to beef or to any ingredient used in the product
  • Women who are pregnant, breast-feeding and of child-bearing potential

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Michael Camilleri, M.D.

Closed for enrollment

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