A Study of an Integrated Approach to Treating Recurrent Lung Adenocarcinomas Resistant to Tyrosine Kinase Inhibitors


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 14-002084
    NCT ID: NCT02616211
    Sponsor Protocol Number: 14-002084

About this study

The purpose of this study is identify molecular changes in recurring lung cancer tumors, and to determine the most significant genes, pathways and clinical characteristics in these lung adenocarcinomas which are resistant to tyrosine kinase inhibitor.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria

  • 18 years or older
  • Lung adenocarcinoma tumors positive for any targetable genetic alterations
  • Have shown by CT/PET scan a partial or no response, progression or recurrence while on or after gene targeted therapy
  • Tumor is accessible for biopsy or surgery
  • Expected life is 6 months or longer


Exclusion Criteria

  • < 18 years
  • Lung cancer other than adenocarcinoma
  • Not able to communicate in English

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jin Jen, M.D., Ph.D.

Closed for enrollment

Contact information:

Shawn Stoddard R.N.




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