A Study of the Effects of not Allowing Sleep in Addition to the Usual Care of Hospitalized Patients with Major Depression

Overview

About this study

This study is to learn how effective a night of no sleep, with or without light therapy, is for patients in an inpatient setting who are experiencing Major depression.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age > 18 years to age 65 at the time of admission, consistent with admission criteria for the Mood Disorders Unit at Mayo Clinic
  • Major Depressive Disorder is, in the judgment of the team physician, the primary diagnosis
  • The reason for admission, as per the judgment of the team physician, is exacerbation of depressive symptoms due to a worsening of MDD (see exclusion criteria below)  

Exclusion Criteria: 

  • Admitted under involuntary orders
  • Inability to understand written or spoken English
  • Inability to provide valid written informed consent because of
    • mental retardation
    • an organic brain syndrome
    • any other reason, as per the judgment of the team physician
  • Primary diagnosis of a bipolar spectrum disorder (bipolar I or II disorder, or bipolar disorder not otherwise specified)
  • The reasons for admission, as per the judgment of the team physician, are not related to exacerbation of MDD, e.g,
    • an adjustment disorder
    • axis II exacerbation
    • effect of substances or substance abuse
    • exacerbation of a comorbid psychiatric disorder
  • Psychotic disorder or history of psychotic features
  • History of seizure disorder
  • History of light-induced migraine
  • Retinal blindness, other retinal disease, severe cataracts, or glaucoma
  • Severe agitation

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Simon Kung, M.D.

Closed for enrollment

Contact information:

Kathleen Poppe M.S.N., R.N.

(507)255-5078

poppe.kathleen@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20164338

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