A Study to See if Collecting Cells with a Brush Will Have a Better Rate of Finding Cancer Cells in the Esophagus


About this study

The purpose of this study is to see if collecting cells from the lining of the esophagus with a brush in addition to the biopsies taken for standard medical care will have a better rate of finding cancer cells related to having Barrett's esophagus.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Age: ≥ 18 years
  • Should have a history of Barrett’s esophagus (with or without dysplasia of either indefinite, low grade or high-grade)
  • Willingness to undergo both WATS and forceps biopsies while undergoing conventional EGD with sedation
  • Ability to provide written, informed consent (approved by IRB) and understand the responsibilities of trial participation
  • Only patients who undergo both forceps biopsies and WATS of the esophagus will be included in this study


Exclusion Criteria

  • Coagulopathy with INR > 2.0, thrombocytopenia with platelet counts < 50,000
  • Is pregnant or planning a pregnancy during the study period
  • History of esophageal, gastric surgery
  • Has undergone ablative therapies
  • Has a known history of unresolved drug or alcohol dependency that would limit ability to comprehend or follow instructions related to informed consent, post-treatment instructions, or follow-up guidelines
  • Patients with inadequate specimens will not undergo a repeat brush biopsy test and will be excluded from the study
  • BE length < 1 cm or > 10 cm
  • Any polypoid/ulcerated lesion > 10mm concerning for invasive cancer on endoscopy
  • Visible lesions that are either submucosal or covered with a clinically intact epithelium

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Kenneth Wang, M.D.

Closed for enrollment

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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