A Study of the Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction


About this study

Ketamine is a commonly used anesthetic medication which is used for induction of anesthesia as well as as an analgesic. It has been shown to have anti-inflammatory properties which may decrease post-operative complications following cardiac surgery with cardiopulmonary bypass that are thought to associated with inflammation. Some studies have shown that ketamine does decrease these complications when compared with anesthetics that are not commonly used in our cardiac anesthesiology practice. Propofol is another commonly used anesthetic medication which is used for induction of anesthesia. Ketamine has not been compared with propofol for potential to reduce post-operative complications associated with the inflammatory process. This study aims to see if ketamine will reduce the incidence of cognitive dysfunction, delirium, and renal dysfunction in comparison with propofol. In addition, the hemodynamic impact of ketamine compared with propofol will be investigated.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Scheduled to undergo cardiac surgery

Inclusion Criteria:

  • Age greater than or equal to 70 years presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota
  • Schedule to undergo complex cardiac surgery
    • Complex cardiac surgery will be defined as surgery involving more than one heart valve, redo-sternotomy procedures, or combined valvular and CABG procedures

Exclusion Criteria:

  • Left or right ventricular assist device implantation or explantation
  • Procedures not requiring cardiopulmonary bypass
  • Active infection or sepsis, severe hepatic disease or ascites
  • Pre-operative renal dysfunction including a baseline creatinine equal to or greater than 2.0 mg/dL or requiring dialysis
  • Immunosuppressive medication use (including steroid use)
  • Immunodeficiency syndrome
  • Known neurologic or psychiatric disorder or
  • Use of drugs for psychosis

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Erica Wittwer, M.D., Ph.D.

Closed for enrollment

Contact information:

Lavonne Liedl R.R.T., L.R.T.

(507) 255-1828


More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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